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The principles of moral management followed the concepts of eighteenth century moral philosophers, and the British concept of associationism, that psychological states and processes are sequentially determined by prior experience and governed by the laws of association Individual differences were explained as a consequence of differing particular sequences of experiences, especially those of education This view led to the optimistic belief that, based on proper education, it would be possible to plan a utopian society to achieve a universal social harmony Associationism owed a debt to John Locke (1632 1704) who, in his An Essay Concerning Human Understanding (1700) stated that all our ideas come from experience, rst from sensation and secondly from re ection upon the ideas furnished by sensation Locke believed that in ordinary thought, one idea normally succeeds another by natural or rational connections.

of the code. Hence, every maximal-length codeword in any optimal code has a sibling. Now we can exchange the longest codewords so that the two lowest-probability source symbols are associated with two siblings on the tree. This does not change the expected length, pi li . Thus, the codewords for the two lowest-probability source symbols have maximal length and agree in all but the last bit. Summarizing, we have shown that if p1 p2 pm , there exists an optimal code with l1 l2 lm 1 = lm , and codewords C(xm 1 ) and C(xm ) that differ only in the last bit. Thus, we have shown that there exists an optimal code satisfying the properties of the lemma. We call such codes canonical codes. For any probability mass function for an alphabet of size m, p = (p1 , p2 , . . . , pm ) with p1 p2 pm , we de ne the Huffman reduction p = (p1 , p2 , . . . , pm 2 , pm 1 + pm ) over an alphabet of size m 1 (Figure 5.4). Let Cm 1 (p ) be an optimal code for p , and let Cm (p) be the canonical optimal code for p. The proof of optimality will follow from two constructions: First, we expand an optimal code for p to construct a code for p, and then we

and two endogenous controls, the zein gene for maize and lectin gene for soybean A previous step of multiplex PCR was used, and one primer of each set was labeled The detection limit was below the EU recommendation (025%) for each GMO Xu et al (2006) designed three different microarrays, the rst for the most used regulatory sequences including the 35S promoter, 35S terminator, nos promoter, nos terminator, nptII terminator, and the FMV 35S promoter, while the second microarray treated speci c gene inserts (soybean, cotton, and rapeseed), and the third one was for endogenous controls A previous step of multiplex PCR was done in which the ampli ed fragments were labeled with Cy5-dCTP The detection ranged from 05% (soybean) to 1% (maize) The same research group has also developed a multiplex PCR-microarray for the detection of GM soybean and six GM maizes.

Ampli ed fragments were labeled with Cy5-dCTP; the limit of detection was similar to the other microarray (05 1%) (Xu et al 2007) Leimanis et al developed (2006, 2008) a PCR-Microarray for the detection of ve plant species and three screening sequences (35S promoter, T-nos, and the nptII gene) that has been validated (Leimanis et al 2008) The detection was based on streptavidin-conjugated gold nanoparticles, and the limit of detection was below 03% Schmidt et al (2008) have developed a rapid multiplex PCR-microarray method for screening GM canola It contains probes that are construct-speci c to the 12 approved GM canola lines in Canada, regulatory elements (CaMV 35S promoter, T-nos, and nptII), a canolaspeci c endogenous gene, and endogenous genes from heterologous crops The limit of detection was determined to range from 01% to 05%.

In addition, a real-time PCR array has been developed for universal detection and identi cation of unapproved GMOs that consists of 30 primer-probe sets distributed in a 96-well plate for detection of GM lines, recombinant DNA segments, endoge-.

But, according to Locke, occasionally ideas become fortuitously associated by their contiguity, which explains how even reasonable people may come to hold unreasonable beliefs Locke suggested that mental disorders are extreme instances of such unreasonable beliefs Although this association model of psychopathology attributed sensory defects and abnormalities of movement to structural defects in the nervous system, it explained insanity peculiar ideas, aberrant and incoherent thought processes, inappropriate emotions, and bizarre behaviors as attributable to chains of irrational associations established by unfortunate learning situations Sanity was considered a matter of coherent, rational thought processes and of self-control, with the proper use of the will in the service of reason to control emotions and to guide action (This view has a long.

9.2 9.2.1

Cost Percentage 61.5% 35.0 45.5 27.3 37.5

$ 4,000 16,000 $20,000 ( 8,000) $12,000