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Noncompliance is such a common problem with adolescents that it has been suggested that adolescence per se is a contraindication for receipt of organ transplantation (see discussion in Stuber & Canning, 1998) Age differences in compliance vary as a function of the treatment regimen under study (eg, very young children experience more problems with oral medications; Phipps & DeCuir-Whalley, 1990) Adolescent noncompliance appears most likely when the regimen is related to independence (either rebelling against parental nagging or re ecting reduced parental supervision), undesirable side effects (eg, cosmetic side effects of steroids), or the need for peer conformity.

It seems more likely that the bouts of feeding are in some way linked to the periods of light and dark Under both of the experimental illumination regimes that we have thus far considered the sh restrict their feeding to the period of light So what happens when the lights are left on constantly The sh retain their circadian rhythm, in that they feed during an approximately 12-hour period and they fast during a period of similar length But the onset of these periods is a little later with each day of the experiment, it seems to drift as the days of continual light progress To describe this phenomenon we would say that the rhythm of behavior was free-running (This is still a circadian rhythm because it retains a c 24-hour periodicity.

) Crucially a return to a 12 : 12 h LD environment restores the behavioral rhythm so that it is in phase with the rhythm of illumination The explanation for these observations is as follows The sh have an internal (or endogenous) rhythm of feeding activity with a periodicity of approximately 24 hours (in fact 258 hours), ie they demonstrate a circadian rhythm This rhythm is kept on track by an external cue termed a zeitgeber This German word translates as time-giver and we should think of it in exactly those terms In effect it tells the animal when it is time to initiate the behavior and so sets the rhythm In this case the zeitgeber is the turning on and off of the lights.

This is why the very regular 12 : 12 h LD cycle resulted in a very regular 12-hourly cycle of feeding activity and inactivity and why the rapid 45 : 45 min LD shifts of light and dark resulted in similarly short pulses of feeding and nonfeeding Kept under constant light the animals had no external cue by which to set, or entrain, their internal clock In the absence of the zeitgeber the endogenous rhythm ran to its.

CASE STUDY: Gabriel WAIS-III (Intellectual Assessment)

Some of these challenges are most evident with diabetes because adherence requires eating foods different from what their peers eat and at different times from their peers, refraining from drinking alcohol, and giving oneself injections (which can be readily misinterpreted by both peers and adults as signi cant drug abuse) It is no wonder, then, that some teenagers try to hide their disease status (Johnson, Silverstein, Rosenbloom, Carter, & Cunningham, 1986) Finally, pubertal changes per se may exacerbate problems with metabolic control during adolescence (see Ruggiero & Javorsky, 1999), further complicating good management Relatively little systematic intervention has speci cally targeted adolescent noncompliance with disease management Three studies of social skill training (with peers and/or parents) reported mixed, albeit promising, results with diabetic adolescents, as did one study of family interventions, a study of anxiety management training, and a single-case study of biofeedback training (see Manne, 1998).

Thus, the second difference is negative, establishing that H (Xn |X0 ) is a concave function of n. HISTORICAL NOTES The entropy rate of a stochastic process was introduced by Shannon [472], who also explored some of the connections between the entropy rate of the process and the number of possible sequences generated by the process. Since Shannon, there have been a number of results extending the basic

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Svenningson et al. [50]. Zhang et al. [47]. c Weingartner et al. [60]. d Weingartner et al. [61]. e Ferron et al. [145]. f Baltensperger et al. [109].

3.6 3.2 2.8 2.4 [Fe] ( M) 2.0 1.6 1.2 0.8 Fe(II) 0.4 0.0 0 5 10 Time (min) 15 20 25 Fe(III) Fe reac

Most other chronic-disease interventions have focused on children or a mixed group of adolescents and children There have also been many and varied interventions with adolescents that have targeted noncompliance with regimens such as dental.