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Face validity is an indication of whether the behavioral and pharmacological qualities of an animal model are similar in nature to those seen in the human condition Construct validity is assessed by determining whether there is a sound theoretical rationale between the animal model and the human condition being modeled (Willner, 1991) Table 71 addresses the questions that assess the validity of each animal model discussed next as related to nicotine addiction Several animal models have been used to examine the reinforcing effects of nicotine In the following paragraphs, we discuss methodology, ndings directly related to nicotine addiction, and validity (see Table 71) of two frequently used animal models, the self-administration and the placeconditioning paradigms Self-Administration The self-administration (SA) paradigm provides a measure of the reinforcing effects of drugs.

18.12 18.12.1

The animal learns the relationship of its behavior such as pressing a lever or a nosepoke and a reinforcer such as an iv injection of a drug If the relationship between the animal s behavior and the response is reinforcing, the probability of the animal continuing the behavior is increased It has taken 10 to 15 years of research with animals to map out the conditions that will support reliable SA of nicotine Nicotine SA has been demonstrated in nonhuman primates (Goldberg, Spealman, & Goldberg, 1981), rats (Corrigall & Coen, 1989; Donny, Caggiula, Knopf, & Brown, 1995), and mice (Picciotto et al, 1998; Stolerman, Naylor, Elmer, & Goldberg, 1999) The role of the mesocorticolimbic dopamine system in mediating nicotine SA has also been examined For example, lesions of dopaminergic neurons in the NAc, and administration of.

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(13)

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system. The wait staff is then responsible for the collection of sales revenue from the guests since the amount to be collected is already in the POS system. In particular, a spreadsheet program can be used for producing the daily receiving report and completing all the calculations necessary for preparation of a standard versus actual cost form, as illustrated in Exhibits 5.15, 5.16, and 5.17.

Every UserForm and control has a Tag property. This property doesn t represent anything specific, and, by default, is empty. You can use the Tag property to store information for your own use. For example, you may have a series of TextBox controls in a UserForm. The user may be required to enter text into some, but not all of them. You can use the Tag property to identify (for your own use) which fields are required. In this case, you can set the Tag property to a string such as Required. Then when you write code to validate the user s entries, you can refer to the Tag property. The following example is a function that examines all TextBox controls on UserForm1 and returns the number of required TextBox controls that are empty: Function EmptyCount() Dim ctl As Control EmptyCount= 0 For Each ctl In UserForm1.Controls If TypeName(ctl) = TextBox Then If ctl.Tag = Required Then If ctl.Text = Then EmptyCount = EmptyCount + 1 End If End If End If Next ctl End Function As you work with UserForms, you will probably think of other uses for the Tag property.

Activate any worksheet, and select File Save As. Then select Microsoft Excel Addin (*.xla) from the Save as type drop-down list.

muscles and/or whole boneless cuts from some of the larger common animal species, such as cattle, sheep, deer, and pigs.

Anonymity or acceptation; Limited use only for the associated service and for the right duration corresponding to this service; Need of the service provider to inform the user how localization data should be used (in case a third party is involved, for example); Possibility for the user to temporarily withdraw his acceptation, freely and easily, for each transaction; Access to these data should be restricted to people acting under the provider s authority.

Now just replace the configuration line in the plugin file to use the config value stored in the database, with the default value being jerk :

PRICE AND COST LEVEL CHANGES (INFLATION OR DEFLATION)

Also, you have the option to allow your children to view restricted content only if they type the proper password. To create a password: a. Click the Create Password button. b. A window opens into which you should type a password as well as a hint to help your children remember the password. c. When you re nished, click OK. d. Click the Advanced tab. Here you have the option to use a ratings bureau or PICSRules to lter Web content (see Figure 15-6).

A parallel is a circle at the Earth s surface being perpendicular to and centered on the North South axis of the Earth. A parallel de nes locations of equal latitude.

the reduction of the costs of health care delivery across a wide range of medical conditions in affected or at-risk populations.

Suppose you have a photo blog posting daily photos, all named using the YYYYMMDD.jpg convention and relying on the filesystem to predict image locations. A standard archive might look something like this:

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